Paxil (paroxetine) is an antidepressant that’s FDA-approved to deal with a number of psychological well being situations. Paxil is in a category of medicine referred to as selective serotonin reuptake inhibitors (SSRIs), which alter serotonin ranges within the mind to enhance temper.  

Paxil is authorised to deal with:

• Main depressive dysfunction (MDD) 
• Generalized nervousness dysfunction
• Panic dysfunction 
• Social nervousness dysfunction 
• Obsessive-compulsive dysfunction (OCD) 
• Premenstrual dysphoric dysfunction (PMDD) 
• Submit-traumatic stress dysfunction (PTSD)

Off-label (that means it hasn’t been FDA-approved to deal with however has been discovered efficient), Paxil might be prescribed to deal with OCD in kids and irritable bowel syndrome.

Analysis exhibits that Paxil is without doubt one of the most potent SSRIs in the marketplace. Whereas it will possibly successfully deal with a number of psychological well being situations, it’s necessary to notice that like most drugs, it additionally has unwanted side effects. In actual fact, Paxil may need extra unwanted side effects than another SSRIs. Earlier than you’re taking Paxil (or any treatment), it’s necessary to speak to your physician about potential dangers you ought to be conscious of.

Being aware of potential penalties is crucial — proceed studying to study in regards to the varied unwanted side effects of Paxil it’s best to find out about earlier than beginning therapy.

Frequent Facet Results of Paxil

Many unwanted side effects of Paxil are gentle and subside as your physique adjusts to the treatment. 

Uncomfortable side effects of Paxil can embrace:

• Nausea
• Weak spot
• Drowsiness 
• Weak spot 
• Sexual dysfunction
• Threat of bleeding
• Weight acquire

Nausea 

Nausea is without doubt one of the unwanted side effects Paxil could cause. Nausea can range in depth, however usually subsides inside a number of days or perhaps weeks. In case you expertise nausea whereas taking Paxil, you may wish to strive consuming smaller meals extra steadily all through the day or taking your treatment with/with out meals.  

Sleeping issues

Sleeping issues are one other widespread facet impact related to taking Paxil. This might imply experiencing issue falling asleep or waking up unexpectedly in the course of the night time. In case you’re having points falling or staying asleep these days, strive going to mattress on the identical time every night time, avoiding caffeine late within the day, and limiting your use of electronics earlier than bedtime.

Drowsiness 

Based on some analysis, Paxil use might trigger extra drowsiness than different antidepressants. Nonetheless, this typically subsides when you turn into accustomed to Paxil’s results in your physique.

Weak spot 

Weak spot is one other facet impact that Paxil customers expertise. This, too, will seemingly resolve as you turn into used to the drugs. If the fatigue turns into an excessive amount of, your physician may wish to take into account speaking about lowering your dose so that you don’t really feel overwhelmed all through your day.  

Sexual dysfunction

Sexual dysfunction is an unlucky chance when utilizing SSRIs like Paxil. Some analysis suggests Paxil may need the highest charge of sexual dysfunction of all of the medicine on this class. It is because Paxil impacts hormones liable for libido, thus resulting in a lowered need for intercourse and different points like delayed ejaculation.

Threat of bleeding

There’s an elevated danger of bleeding when taking SSRIs comparable to Paxil. That mentioned, this isn’t essentially one thing it’s worthwhile to fear about except you might have different danger components for bleeding.

Weight acquire

Weight acquire is usually related to Paxil greater than different SSRIs. How a lot you may acquire relies upon closely upon components like way of life decisions, physique chemistry, and weight earlier than beginning Paxil. Study extra about Paxil weight acquire for extra data.

“Decreased sexual need, delayed ejaculation, nausea, diarrhea, and constipation are widespread unwanted side effects. Please attain out to your physician in the event that they worsen.”

– Talkspace psychiatrist Dr. Dion Metzger

Severe Facet Results of Paxil

Paxil might assist deal with melancholy and nervousness, however it will possibly additionally result in extreme adversarial reactions.

Serotonin syndrome

Extra serotonin within the physique could cause a critical and probably life-threatening situation referred to as serotonin syndrome. Serotonin syndrome is a possible facet impact that’s extra widespread in individuals who take increased doses of Paxil. 

Signs embrace agitation, confusion, sweating, muscle twitching and spasms, fever, and elevated coronary heart charge. When you’ve got any signs of serotonin syndrome whereas on Paxil — or another SSRI antidepressant — get medical assist instantly.  

Antidepressant Discontinuation Syndrome

When stopping Paxil abruptly or lowering the dosage too shortly, it will possibly result in what’s generally known as antidepressant discontinuation syndrome. This happens when your mind can’t modify shortly sufficient to decrease serotonin ranges. 

Frequent indicators might contain feeling queasy, lightheadedness, exhaustion, and flu-like sensations comparable to aches and chills. In some instances, there may additionally be vivid desires or nightmares that would last as long as a number of weeks after stopping the treatment abruptly. To keep away from this kind of response, it’s finest to slowly cut back your dose over time with steering out of your physician reasonably than quitting chilly turkey by yourself.

Threat of suicidal ideas and behaviors

It’s important that healthcare suppliers intently monitor individuals taking Paxil long-term, as the chance of suicidal ideas and behaviors might happen in uncommon instances. Report any agitation, restlessness, irritability, hostility, aggression, or impulsivity — notably for those who’re having suicidal ideas — so you may obtain quick consideration.

How Lengthy Do Paxil Facet Results Final?

When utilizing Paxil, first-week unwanted side effects might be worse for some individuals. Uncomfortable side effects can range in length and severity relying on the person. Many individuals might expertise some degree of adversarial reactions for as much as a month after starting the treatment. After this era, it’s widespread for signs to subside. In very uncommon cases, unwanted side effects can last more than 4 weeks.

“Ready for unwanted side effects to resolve after 1 – 2 weeks is really useful. This works for gastrointestinal unwanted side effects comparable to nausea, diarrhea, and constipation. Sexual unwanted side effects might not resolve with time. Talk together with your physician you probably have issues.”

– Talkspace psychiatrist Dr. Dion Metzger

Lengthy-Time period Facet Results of Paxil

The Nationwide Alliance on Psychological Sickness (NAMI) notes there usually aren’t any critical, widespread long-term unwanted side effects of Paxil it’s worthwhile to be involved with, so long as you employ the treatment as directed. 

Handle Paxil Facet Results

Be aware of the potential repercussions when using Paxil. Addressing the attainable unwanted side effects may help make sure you acquire most profit from the prescription drug. Listed below are some suggestions for managing Paxil unwanted side effects:

• Begin with a low dose and step by step enhance as wanted — Beginning at a decrease dose might cut back the chance of experiencing particular unwanted side effects like nausea or complications. Talk about together with your physician the very best dosage to your signs. 
• Take with meals — Taking Paxil with meals might cut back abdomen upset or different digestive points.
• Keep hydrated — Consuming loads of fluids all through the day may help decrease dizziness and lightheadedness brought on by Paxil use.
• Keep away from alcohol — Alcohol consumption ought to usually be prevented whereas on any kind of antidepressant treatment, together with Paxil, as it will possibly intervene with its effectiveness and trigger undesirable reactions in some individuals.
• Train frequently — Common train has constructive advantages on psychological well being. Be sure that to not overexert your self throughout exercises for those who really feel drained or weak attributable to treatment utilization.
• Monitor temper modifications intently — If experiencing any sudden modifications in temper whereas taking Paxil, contact your physician instantly to allow them to present medical recommendation and may modify your dosage if mandatory or suggest various therapy choices.

If unwanted side effects don’t disappear, speak to a health care provider earlier than stopping Paxil treatment. Stopping abruptly may end up in Paxil withdrawal signs.

See If Paxil Is Proper for You with Talkspace Psychiatry

Regardless of its effectiveness in treating psychological well being situations, Paxil could cause adversarial results that needs to be thought of earlier than utilization. Talkspace Psychiatry supplies a web-based platform for individuals desirous to discover if Paxil is true for them. Join with licensed psychiatrists and psychological well being care suppliers who concentrate on psychological healthcare and drugs administration.

Talkspace presents complete assessments of every affected person’s medical historical past and present signs to find out whether or not or not Paxil can be a very good match for his or her wants. In the event that they do discover it a very good match, they might prescribe you Paxil on-line as a part of your therapy plan. Get began with Talkspace immediately. 

Sources:

1. PAXIL- paroxetine hydrochloride pill, movie coated . U.S. Meals and Drug Administration. https://www.fda.gov/trade/fda-data-standards-advisory-board/structured-product-labeling-resources. Accessed March 26, 2023. 
2. Davis BA, Nagarajan A, Forrest LR, Singh SK. Mechanism of paroxetine (paxil) inhibition of the serotonin transporter. Scientific Reviews. 2016;6(1). doi:10.1038/srep23789. https://www.nature.com/articles/srep23789. Accessed March 26, 2023.
3. Marken PA. Choosing a selective serotonin reuptake inhibitor. The Main Care Companion For CNS Issues. 2000;2(6). doi:10.4088/pcc.v02n0602. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC181142/. Accessed March 26, 2023.
4. Montejo AL, Llorca G, Izquierdo JA, Rico-Villademoros F. Incidence of sexual dysfunction related to antidepressant brokers: a potential multicenter research of 1022 outpatients. J Clin Psychiatry. 62(3):10-21. https://pubmed.ncbi.nlm.nih.gov/11229449/. Accessed March 26, 2023.
5. Sanchez C, Reines EH, Montgomery SA. A comparative assessment of Escitalopram, Paroxetine, and sertraline. Worldwide Medical Psychopharmacology. 2014;29(4):185-196. doi:10.1097/yic.0000000000000023. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4047306/. Accessed March 26, 2023.
6. Paroxetine (paxil). NAMI. https://www.nami.org/About-Psychological-Sickness/Therapies/Psychological-Well being-Medicines/Varieties-of-Remedy/paroxetine-(paxil). Accessed March 26, 2023.